Endocrine Abstracts

A 60-year-old South African male, presented as an emergency with a 4 week history of lethargy, polyuria, increased thirst, constipation and weight loss. Blood tests revealed hypercalcemia with CCa-4.72 mmol/l, PTH-159.3pmol/l and 25 OH Vitamin D 22mmol/l. Intensive iv hydration was followed by IV Pamidronate 60 mg stat. Calcitonin (4 units/Kg tds) was started 48 hours later which resulted in a fall in the calcium to 2.66 by day 5. Cinacalcet 30 mg od was then introduced such t...

Transient mild hyperthyroidism is fairly common in women with hyperemesis gravidarum, occurring in up to two-thirds of them. It is also a well known fact that pregnant women with severe hyperemesis gravidarum can progress to develop Wernicke’s encephalopathy. Hyperthyroidism, without any other risk factors, has been described to accelerate the process of thiamine depletion as well. This is much less recognised.We describe the case of a 32-year-old P...

Adrenoleukodystrophy (ALD) is an X-linked, widely heterogeneous, neurodegenerative disorder of peroxisomal metabolism characterised by the accumulation of very-long-chain fatty acids (VLCFA). A mutation in the ABCD1 gene is responsible. ALD has both a neurological and an endocrine interface as VLCFA deposit in the central and peripheral nervous system as well as the adrenal cortex and testis. ALD can present in childhood with a cerebral form or later in life as an adrenomyelon...

Hypercalcemia is uncommon in lymphoma, it is generally a feature of histologically high grade disease with other aggressive clinical features, such as the presence of B symptoms and an elevated lactate dehydrogenase (LDH). The mechanism of hypercalcaemia is unknown but there is strong evidence for humoral factors that may or may not be related to parathyroid hormone (PTH).Case: A 92-year-old lady who was found to have incidental hypercalcaemia (calcium 2...